Intra?individual cytokine profile in peri?implantitis and periodontitis: A cross?sectional study

Aim To study cytokine profiles and intra-individual correlations in crevicular fluid samples at periodontitis, peri-implantitis, healthy sites. Materials methods Samples from gingival (GCF) peri-implant (PICF) were collected diseased sites patients who had dental implants for a minimum of 10 years. Cytokine levels analyzed using the Bio-Plex Pro Human inflammation kit, which included biomarkers tumor necrosis factor-? (TNF-?) superfamily, regulatory T Cell (Treg) cytokines, interferon (IFN) proteins. Results Gingival fluid/PICF levels, determined 163 patients, frequently lower tooth implant compared to with periodontitis or peri-implantitis. In contrast, there no significant differences between Intra-individual cytokines significant. addition, IFN-?1 TNFSF12 significantly correlated presence Conclusion Within limits this study, profile did not differ diagnosed those but Studying is method elucidate possible etiopathogeneses since it well known that immune responses dysbiosis vary individuals according host factors. Thus, findings present are potentially relevant advancement knowledge field.